Wikipedia dice:

Some mangosteen juice products contain whole fruit purée or polyphenols extracted from the inedible exocarp (rind) as a formulation strategy to add phytochemical value. The resulting juice has purple color and astringency derived from exocarp pigments, including xanthones under study for potential anti-disease effects.[9] However, as xanthone research is at an early stage of basic laboratory research and only preliminary evidence has been found for anti-disease activity, no conclusions about possible health benefits for humans are warranted presently.

Furthermore, a possible adverse effect may occur from chronic consumption of mangosteen juice containing xanthones. A 2008 medical case report described a patient with severe acidosis possibly attributable to a year of daily use (to lose weight, dose not described) of mangosteen juice infused with xanthones.[10] The authors proposed that chronic exposure to alpha-mangostin, a xanthone, could be toxic to mitochondrial function,[11] leading to impairment of cellular respiration and production of lactic acidosis.


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