codice:
UPDATE table SET Col1 = CASE id 
                          WHEN 1 THEN 1 
                          WHEN 2 THEN 2 
                          WHEN 4 THEN 10 
                          ELSE Col1 
                        END, 
                 Col2 = CASE id 
                          WHEN 3 THEN 3 
                          WHEN 4 THEN 12 
                          ELSE Col2 
                        END
             WHERE id IN (1, 2, 3, 4);