Ciao Baluba,

intendi una cosa tipo questa?
codice:
<form name="NomeForm">
	<select name="NomeSelect1" onchange="if(this.form.NomeSelect2.selectedIndex>0){alert('select2 già selezionata');this.selectedIndex=0}">
		<option value="">selezionare...</option>
		<option value="1">uno</option>
		<option value="2">due</option>
		<option value="3">tre</option>
		<option value="4">quattro</option>
	</select>
	<select name="NomeSelect2" onchange="if(this.form.NomeSelect1.selectedIndex>0){alert('select1 già selezionata');this.selectedIndex=0}">
		<option value="">selezionare...</option>
		<option value="1">uno</option>
		<option value="2">due</option>
		<option value="3">tre</option>
		<option value="4">quattro</option>
	</select>
</form>